You should always take regular backups of your data files. Due to the way the local database works, it is important that Geneious is not accessing the database when a backup is taken. The safest way to make a backup is to use the Backup button, which will cause Geneious to cease working on the local database and make a zip archive. This file should be stored on another drive.
General system backups can also be used as long as these are made when Geneious is in a non-running state. For example, Mac users with Time Machine will have backups taken during the day but if Geneious is running when those backups are taken, they may not be suitable for restoring from as some files may be incompletely copied. Backups taken overnight when Geneious isn’t running would be fine.